Faculty

Aditya Bardia, MD, MPH, FASCO

Program Director, Breast Medical Oncology
Assistant Chief (Translational Research), Division of Hematology-Oncology
Professor of Medicine, Geffen School of Medicine, University of California Los Angeles
Director of Translational Research Integration, UCLA Health Jonsson Comprehensive Center
Los Angeles, California

Virginia Kaklamani, MD, DSc

Professor of Medicine
Ruth McLean Bowman Bowers Chair in Breast Cancer Research and Treatment
A.B. Alexander Distinguished Chair in Oncology
Leader
Breast Oncology Program
UT Health San Antonio
MD Anderson Cancer Center
San Antonio, Texas

Sarah Sammons, MD

Assistant Professor of Medicine
Dana-Farber Cancer Institute
Harvard Medical School
Boston, Massachusetts

Provided by

Provided by Clinical Care Options, LLC

Supporters

Supported by educational grants from AstraZeneca and Lilly.

AstraZeneca

Lilly

Target Audience

This program is intended for medical oncologists and other healthcare professionals who treat patients with breast cancer.

Program Learning Goal

The goal of this program is to improve the knowledge, confidence, and competence of learners to integrate available clinical data on oral SERDs into practice for patients with hormone receptor–positive, HER2-negative breast cancer.

Learning Objectives

Upon completion of this activity, participants should be able to:

Plan individualized treatment with oral SERDs for patients with HR+/HER2- mBC progressing on first-line endocrine therapy based on individual patient and disease characteristics, genomic profile, available clinical data, current guidelines, and expert recommendations
Effectively mitigate and manage toxicities associated with oral SERD therapy for patients with HR+/HER2- breast cancer
Implement recommended strategies to improve adherence to and persistence with oral SERD therapy in patients with HR+/HER2- breast cancer
Identify patients with HR+/HER2- breast cancer who may be eligible for enrollment on a clinical trial investigating oral SERDs or other precision medicine approaches

Disclosure

Clinical Care Options, LLC (CCO) requires instructors, planners, managers, and other individuals who are in a position to control the content of this activity to disclose all financial conflicts of interest (COI) they may have with ineligible companies. All relevant COI are thoroughly vetted and mitigated according to CCO policy. CCO is committed to providing its learners with high-quality CME/CE activities and related materials that promote improvements or quality in healthcare and not a specific proprietary business interest of an ineligible company.

The faculty reported the following relevant financial relationships or relationships to products or devices they have with ineligible companies related to the content of this educational activity:

Primary Author

Aditya Bardia, MD, MPH, FASCO

Aditya Bardia, MD, MPH, FASCO: consultant/advisor/speaker: Daiichi Sankyo/AstraZeneca, Genentech, Gilead, Lilly, Menarini, Merck, Novartis, Pfizer, Sanofi; researcher: Daiichi Sankyo/AstraZeneca, Genentech, Gilead, Menarini, Merck, Novartis, Pfizer, Sanofi.

Virginia Kaklamani, MD, DSc

Virginia Kaklamani, MD, DSc: consultant/advisor/speaker: AstraZeneca, Genentech, Gilead, Menarini.

Sarah Sammons, MD

Assistant Professor of Medicine
Dana-Farber Cancer Institute
Harvard Medical School
Boston, Massachusetts

Sarah Sammons, MD: researcher: AstraZeneca, Lilly, Relay, Seagen, Sermonix; consultant/advisor/speaker: AstraZeneca, Daichii Sankyo, Gilead, Novartis, Pfizer.

The planners and content peer reviewers from Clinical Care Options, LLC do not have any relevant financial relationships to disclose.

Instructions for Credit

Participation in this self-study activity should be completed in approximately 1.5 hours. To successfully complete this activity and receive credit, participants must follow these steps during the period from June 18, 2024, through June 17, 2025:

Login or Sign Up for an account by clicking at the top of this page.
Read the target audience, learning objectives, and faculty disclosures.
View and study the content in its entirety.
Submit answers to the posttest questions and evaluation questions online.

You must receive a test score of at least 65 and respond to all evaluation questions to receive a certificate. After submitting the evaluation, you may access your online certificate by selecting the certificate link on the confirmation page. Records of all CME/CE activities completed can be found on the "My Certificates" page. There are no costs/fees for this activity.

Format

This program has been made available online.

Disclosure of Unlabeled Use

This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. The planners of this activity do not recommend the use of any agent outside of the labeled indications.

The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of the planners. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.

Disclaimer

Participants have an implied responsibility to use the newly acquired information to enhance patient outcomes and their own professional development. The information presented in this activity is not meant to serve as a guideline for patient management. Any procedures, medications, or other courses of diagnosis or treatment discussed or suggested in this activity should not be used by clinicians without evaluation of their patient’s conditions and possible contraindications and/or dangers in use, review of any applicable manufacturer’s product information, and comparison with recommendations of other authorities.

Accreditation

Joint Accreditation Statement

In support of improving patient care, Clinical Care Options, LLC (CCO) is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

Physician Continuing Medical Education

CCO designates this enduring material for a maximum of 1.5 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

American Board of Internal Medicine Maintenance of Certification

Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 1.5 MOC points in the American Board of Internal Medicine’s (ABIM) Maintenance of Certification (MOC) program. It is the CME activity provider’s responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit.

For ABIM MOC points, your information will be shared with the ABIM through CCO's Joint Accreditation Program and Activity Reporting System (JAPARS). Please allow 6-8 weeks for your MOC points to appear on your ABIM records.

By sharing your Diplomate Board ID # and DOB, you are giving Clinical Care Options, LLC permission to use this information/data to report your participation to these Boards via the Joint Accreditation Program and Activity Reporting System (JA-PARS).

CME Passport

The CME credits that physicians earn from this activity will be submitted to ACCME's CME Passport, a free, centralized web application where you can create a personalized account to view, track, and generate transcripts of your reported CME credit. Visit www.cmepassport.org to create your account.

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Next-Generation Therapeutics for HR+/HER2- Breast Cancer: Spotlight on SERDs

Video