Faculty

Todd M. Bauer, MD

Medical Oncologist
Tennessee Oncology, PLLC
Greco Hainsworth Centers for Research
Nashville, Tennessee

James M. Cleary, MD, PhD

Associate Professor of Medicine
Harvard Medical School
Dana-Farber Cancer Institute
Boston, Massachusetts

Yin (Rex) Hung, MD, PhD

Associate Professor of Pathology
Harvard Medical School
Medical Director
Histology and Ancillary Diagnostic Laboratories
Associate Pathologist
Department of Pathology
Massachusetts General Hospital
Boston, Massachusetts

Funda Meric-Bernstam, MD

Chair, Department of Investigational Cancer Therapeutics
Medical Director, Institute for Personalized Cancer Therapy
Nellie B. Connally Chair in Breast Cancer
The University of Texas MD Anderson Cancer Center
Houston, Texas

Lei Zhao, MD, PhD

Associate Pathologist
Department of Pathology
Brigham & Women's Hospital
Assistant Professor
Harvard Medical School
Boston, Massachusetts

Provided by

Provided by Clinical Care Options, LLC

Supporters

Supported by educational grants from AstraZeneca, Daiichi Sankyo, Inc., and Jazz Pharmaceuticals.

AstraZeneca

Daiichi Sankyo, Inc.

Jazz Pharmaceuticals

Target Audience

This educational activity is intended for pathologists, oncologists, and other healthcare professionals in the precision care of HER2-altered solid tumors.

Program Learning Goal

This activity aims to improve learners' knowledge, confidence, and competence in accurately performing pathological assessment, diagnosing, and reporting results to provide evidence-based treatment strategies for patients with HER2-altered solid tumors.

Learning Objectives

Upon completion of this activity, participants should be able to:

Implement pathological procedures to consistently and accurately identify patients who may benefit from HER2-targeted therapy through a proper understanding of HER2 status across solid tumors and the use of guideline and expert-recommended testing
Summarize the importance of proper HER2 evaluation through consideration of current and emerging clinical trial data and recent FDA-approved indications to inform patient care
Identify barriers to pathological assessment and implement approaches to standardize HER2 scoring and reporting in clinical practice
Collaborate with the multidisciplinary team to optimize therapeutic strategies for patients with HER2-altered solid tumors

Disclosure

Clinical Care Options, LLC (CCO) requires instructors, planners, managers, and other individuals who are in a position to control the content of this activity to disclose all financial conflicts of interest (COI) they may have with ineligible companies. All relevant COI are thoroughly vetted and mitigated according to CCO policy. CCO is committed to providing its learners with high-quality CME/CE activities and related materials that promote improvements or quality in healthcare and not a specific proprietary business interest of an ineligible company.

The faculty reported the following relevant financial relationships or relationships to products or devices they have with ineligible companies related to the content of this educational activity:

Primary Author

Todd M. Bauer, MD: consultant/advisor/speaker: Bayer, FMI, Pfizer, Tempus.

James M. Cleary, MD, PhD: consultant/advisor/speaker: Gilead; researcher: Arcus, GlaxoSmithKline, Merck, Pyxis; data and safety monitoring committee: AstraZeneca.

Yin (Rex) Hung, MD, PhD, has no relevant financial relationships to disclose.

Funda Meric-Bernstam, MD: consultant/advisor/speaker: AstraZeneca, Becton Dickinson, Calibr (Scripps), Cybrexa, Daiichi Sankyo, Dava Oncology, Debiopharm, EcoR1, eFFECTOR, Elevation Oncology, Exelixis, go Therapeutics, GT Apeiron, Guardant Health, Harbinger Health, Incyte, Jazz, Kivu Biosciences, LegoChem Bio, Loxo Oncology, Menarini, Mersana, Molecular Templates, OnCusp, Protai Bio, Ribometrix, Seagen, Tempus, Theratechnologies, Zentalis, Zymeworks; researcher (paid to institution): Aileron, AstraZeneca, Bayer, Calithera Bioscience, Curis, CytomX, Daiichi Sankyo, Debiopharm, eFFECTOR, Genentech, Guardant Health, Jazz, Klus, Takeda, Novartis, Puma Biotechnology, Taiho, Zymeworks; other financial or material support: Dava Oncology.

Lei Zhao, MD, PhD: researcher: Incyte.

The planners and content peer reviewers from Clinical Care Options, LLC do not have any relevant financial relationships to disclose.

Instructions for Credit

Participation in this self-study activity should be completed in approximately 1.25 hours. To successfully complete this activity and receive credit, participants must follow these steps during the period from April 21, 2025, through October 20, 2025:

Login or Sign Up for an account by clicking at the top of this page.
Read the target audience, learning objectives, and faculty disclosures.
View and study the content in its entirety.
Submit answers to the posttest questions and evaluation questions online.

You must receive a test score of at least 65 and respond to all evaluation questions to receive a certificate. After submitting the evaluation, you may access your online certificate by selecting the certificate link on the confirmation page. Records of all CME/CE activities completed can be found on the "My Certificates" page. There are no costs/fees for this activity.

Format

This program has been made available online.

Disclosure of Unlabeled Use

This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. The planners of this activity do not recommend the use of any agent outside of the labeled indications.

The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of the planners. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.

Disclaimer

Participants have an implied responsibility to use the newly acquired information to enhance patient outcomes and their own professional development. The information presented in this activity is not meant to serve as a guideline for patient management. Any procedures, medications, or other courses of diagnosis or treatment discussed or suggested in this activity should not be used by clinicians without evaluation of their patient’s conditions and possible contraindications and/or dangers in use, review of any applicable manufacturer’s product information, and comparison with recommendations of other authorities.

Accreditation

Joint Accreditation Statement

In support of improving patient care, Clinical Care Options, LLC (CCO) is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

Physician Continuing Medical Education

CCO designates this enduring material for a maximum of 1.25 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

American Board of Internal Medicine Maintenance of Certification

Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 1.25 MOC point in the American Board of Internal Medicine’s (ABIM) Maintenance of Certification (MOC) program. It is the CME activity provider’s responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit.

For ABIM MOC points, your information will be shared with the ABIM through CCO's Joint Accreditation Program and Activity Reporting System (JAPARS). Please allow 6-8 weeks for your MOC points to appear on your ABIM records.

By sharing your Diplomate Board ID # and DOB, you are giving Clinical Care Options, LLC permission to use this information/data to report your participation to these Boards via the Joint Accreditation Program and Activity Reporting System (JA-PARS).

American Board of Pathology Continuing Certification

Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 1.25 Lifelong Learning points in the American Board of Pathology’s Continuing Certification Program. It is the CME activity provider’s responsibility to submit learner completion information to ACCME for the purpose of granting ABPath Continuing Certification (formerly Maintenance of Certification or MOC) credit.

For ABPath Lifelong Learning points, your information will be shared with the ABPath through CCO’s Joint Accreditation Program and Activity Reporting System (JAPARS). Please allow 6-8 weeks for your Lifelong Learning points to appear on your ABPath records.

CME Passport

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The CME credits that physicians earn from this activity will be submitted to ACCME's CME Passport, a free, centralized web application where you can create a personalized account to view, track, and generate transcripts of your reported CME credit. Visit www.cmepassport.org to create your account.

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These terms of use were last updated in July 2021.

Refining Approaches to Overcome Challenges, Enhance Consistency, and Standardize Scoring and Reporting in HER2-Expressing Solid Tumors

Video