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Identification and Management of Bipolar Depression


On-demand webcast recording of the bipolar depression presentation by Larry Culpeper, MD, MPH, and Mark Zimmerman, MD, at the 2023 AAFP FMX Conference.

Physician Assistants/Physician Associates: 1.50 AAPA Category 1 CME credits

Nurses: 1.50 Nursing contact hours

Physicians: maximum of 1.50 AMA PRA Category 1 Credits

Pharmacists: 1.50 contact hours (0.15 CEUs)

Psychologists: 1.50 APA CE Credits

Social Workers: 1.50 ASWB ACE CE Credits

Released: November 14, 2023

Expiration: November 13, 2024



Larry Culpepper

Larry Culpepper, MD, MPH

Professor of Family Medicine
Department of Family Medicine
Boston University School of Medicine
Boston, Massachusetts

Mark Zimmerman

Mark Zimmerman, MD

Chief of Psychiatry and Behavioral Health
South County Psychiatry
Cranston, Rhode Island

Provided by

Provided by Clinical Care Options, LLC

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Supported by an educational grant from Intra-Cellular Therapies, Inc.

Intra-Cellular Therapies, Inc.

Target Audience

This program is intended for healthcare professionals caring for patients with bipolar depression, including physicians (psychiatrists and primary care), nurse practitioners, physician associates, registered nurses, pharmacists, social workers, and psychologists.

Program Learning Goal

The goal of this program is to improve the knowledge, competence, and performance of learners in effort to optimize diagnosis and treatment for patients with bipolar depression.

Learning Objectives

Upon completion of this activity, participants should be able to:

  • Describe the differential diagnosis of bipolar depression based on expert best practices

  • Assess the real-world evidence for use of antidepressants in bipolar depression 

  • Individualize treatment selections for patients with bipolar depression based on characteristics 


Clinical Care Options, LLC (CCO) requires instructors, planners, managers, and other individuals who are in a position to control the content of this activity to disclose all financial conflicts of interest (COI) they may have with ineligible companies. All relevant COI are thoroughly vetted and mitigated according to CCO policy. CCO is committed to providing its learners with high-quality CME/CE activities and related materials that promote improvements or quality in healthcare and not a specific proprietary business interest of an ineligible company.

The faculty reported the following relevant financial relationships or relationships to products or devices they have with ineligible companies related to the content of this educational activity:

Primary Author

Larry Culpepper, MD, MPH

Professor of Family Medicine
Department of Family Medicine
Boston University School of Medicine
Boston, Massachusetts

Larry Culpepper, MD, MPH: consultant/advisor/speaker: AbbVie, Biogen, Eisai, Sage, Sunovion, Supernus.

Mark Zimmerman, MD

Chief of Psychiatry and Behavioral Health
South County Psychiatry
Cranston, Rhode Island

Mark Zimmerman, MD: consultant/advisor/speaker: Biogen, Boehringer Ingelheim, GH Research.

The planners and content peer reviewers from Clinical Care Options, LLC and Practicing Clinicians Exchange do not have any relevant financial relationships to disclose, except Gabrielle Giacona and Michael Asbach, DMSc, PA-C, Psych-CAQ as noted below:

Gabrielle Giacona: individually traded stocks/stock options: AstraZeneca, Moderna.

Michael Asbach, DMSc, PA-C, Psych-CAQ: consultant/advisor/speaker: AbbVie, Avanir, Biogen, Janssen, Karuna, Neurocrine, Otsuka.

Instructions for Credit

Participation in this self-study activity should be completed in approximately 1.5 hours. To successfully complete this activity and receive credit, learners must follow these steps during the period from November 14, 2023, through November 13, 2024:

1. Login or Sign Up for an account by clicking at the top of this page.
2. Read the target audience, learning objectives, and faculty disclosures.
3. View and study the content in its entirety.
4. Submit answers to the posttest questions and evaluation questions online.

You must receive a test score of at least 65% and respond to all evaluation questions to receive a certificate. After submitting the evaluation, you may access your online certificate by selecting the certificate link on the confirmation page. Records of all CME/CE activities completed can be found on the "My Certificates" page. There are no costs/fees for this activity.


This program has been made available online.

Disclosure of Unlabeled Use

This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. The planners of this activity do not recommend the use of any agent outside of the labeled indications.

The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of the planners. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.


Participants have an implied responsibility to use the newly acquired information to enhance patient outcomes and their own professional development. The information presented in this activity is not meant to serve as a guideline for patient management. Any procedures, medications, or other courses of diagnosis or treatment discussed or suggested in this activity should not be used by clinicians without evaluation of their patient’s conditions and possible contraindications and/or dangers in use, review of any applicable manufacturer’s product information, and comparison with recommendations of other authorities.


Joint Accreditation Statement
Joint AccreditationIn support of improving patient care, Clinical Care Options, LLC (CCO) is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC) to provide continuing education for the healthcare team.


Physician Continuing Medical Education
CCO designates this enduring material for a maximum of 1.5 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Nursing Continuing Professional Development
The maximum number of hour awarded for this Nursing Continuing Professional Development activity is 1.5 contact hours.

Physician Associates Continuing Medical Education
Joint AccreditationClinical Care Options has been authorized by the American Academy of PAs (AAPA) to award AAPA Category 1 CME credits for activities planned in accordance with AAPA CME Criteria. This activity is designated for 1.5 AAPA Category 1 CME credit. Approval is valid until  November 13, 2024. PAs should only claim credit commensurate with the extent of their participation.


Continuing Pharmacy Education

CCO designates this continuing education activity for 1.5 contact hour (0.15 CEUs) of the Accreditation Council for Pharmacy Education.
Universal Activity Number - JA4008176-0000-23-297-H01-P
Type of Activity: Application

Upon successfully completing the post-test with a score of 65 and the activity evaluation form, transcript information will be sent to the NABP CPE Monitor Service within 60 days.

As a Jointly Accredited Organization, Clinical Care Options, LLC is approved to offer social work continuing education by the Association of Social Work Boards (ASWB) Approved Continuing Education (ACE) program. Organizations, not individual courses, are approved under this program. Regulatory boards are the final authority on courses accepted for continuing education credit. Social workers completing this course receive 1.5 clinical continuing education credits.


Continuing education (CE) credits for psychologists are provided through the co-sponsorship of the American Psychological Association (APA) Office of Continuing Education in Psychology (CEP). The APA CEP Office maintains responsibility for the content of the programs.

This activity offers 1.5 continuing education credits for psychologists.