Interactive Decision Support Tool - - CLL Global IDST

Interactive Tool With Expert Guidance for the Treatment of CLL: An International Perspective

Released: March 25, 2025

Expiration: September 24, 2025

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About This Tool & Disclaimer

Clinical Care Options, LLC, is grateful to Toby A. Eyre, MBChB, MD; Arnon Kater, MD, PhD; Vincent Ribrag, MD; Stephan Stilgenbauer, MD; and Alessandra Tedeschi, MD, who provided expert guidance, knowledge, and support in the development of this Interactive Decision Support Tool.

Note: Expert recommendations were compiled in February 2025 and include the opinions of the experts at that time.

The goal of this tool is to educate healthcare professionals on making optimal treatment choices for patients with CLL who meet the International Workshop on Chronic Lymphocytic Leukemia criteria for treatment.^{[Hallek 2018]} These criteria include the presence of anemia because of bone marrow failure (hemoglobin <10 g/dL, platelets <100,000 μL), massive or progressive symptomatic lymphadenopathy or splenomegaly, progressive lymphocytosis, and disease-related constitutional symptoms (significant fatigue, unintentional weight loss, night sweats, fevers unrelated to infectious complications).

A series of multiple choice questions allows the user to select individual patient characteristics that are necessary to consider when making treatment choices. These characteristics include mutation status, treatment setting, patient age and fitness, previous therapy, presence of comorbidities, and reason for discontinuing treatment. It should be noted that these are not exclusive characteristics when making choices. Other considerations that are not included in this tool, such as the presence of additional comorbidities, also should be considered, if appropriate, when making overall treatment choices.

Based on the characteristics entered, the tool will display evidence-based recommendations for that specific patient case.

For additional information on the use of BTK inhibitors and best practices in the management of patients with CLL, please follow this link to the program page.

Access to and use of this Interactive Decision Support Tool titled, “Interactive Tool With Expert Guidance for the Treatment of CLL: An International Perspective” is provided subject to the following terms and conditions. PLEASE READ THESE TERMS CAREFULLY.

This Interactive Decision Support Tool is designed to educate healthcare professionals on making optimal management choices for treating patients with CLL. The information provided is based on expert guidance from Toby A. Eyre, MBChB, MD; Arnon Kater, MD, PhD; Vincent Ribrag, MD; Stephan Stilgenbauer, MD; and Alessandra Tedeschi, MD.

The material published by Clinical Care Options reflects the views of the reviewers or authors of the material, not those of Clinical Care Options, LLC, the accredited provider, or the companies providing educational grants. The materials may discuss uses and dosages for therapeutic products that have not been approved by the FDA. A qualified healthcare professional should be consulted before using any therapeutic product discussed. Readers should verify all information and data before treating patients or using any therapies described in these materials.

Although the information contained in the “Interactive Tool With Expert Guidance for the Treatment of CLL: An International Perspective” Interactive Decision Support Tool has been produced and processed from sources believed to be reliable, no warranty, expressed or implied, is made regarding the accuracy, adequacy, completeness, legality, reliability, or usefulness of any information. This disclaimer applies to both the isolated and aggregate uses of the information. Clinical Care Options provides this information on an as-is basis. This disclaimer applies to all material published by Clinical Care Options including but not limited to medical information or opinions. All warranties of any kind, expressed or implied, including but not limited to the implied warranties of merchantability, fitness for a particular purpose, freedom from contamination by computer viruses, and noninfringement of proprietary rights are disclaimed.

Any trademarks are the property of the respective companies.

Program Content

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