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Rett Syndrome: From Pathophysiology to Modern Research and Novel Therapies

Clinical Thought

Learn about the current landscape of diagnosis and treatment for patients with Rett syndrome, including origins, common presentations, multidisciplinary management, and new and emerging therapies for this neurodevelopmental disorder.

Nurses: 0.25 Nursing contact hour

Pharmacists: 0.25 contact hour (0.025 CEUs)

Physicians: maximum of 0.25 AMA PRA Category 1 Credit

Released: May 22, 2024

Expiration: May 21, 2025



Arthur A. Beisang

Arthur A. Beisang, MD

Complex Care Pediatrician
Gillette Children’s Specialty Healthcare
Assistant Professor of Pediatrics
University of Minnesota
Minneapolis, Minnesota

Provided by

Provided by Clinical Care Options, LLC, in partnership with the International Rett Syndrome Foundation (IRSF).

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Supported by an educational grant from Acadia Pharmaceuticals Inc.

Acadia Pharmaceuticals, Inc.


International Rett Syndrome Foundation (IRSF)

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Target Audience

This program is intended for neurology-focused healthcare professionals caring for patients with Rett Syndrome including neurologists, nurse practitioners, physician associates, nurses, and pharmacists.

Program Learning Goal

The goal of this program is to improve the knowledge and competence of learners in effort to optimize management of patients with Rett syndrome.

Learning Objectives

Upon completion of this activity, participants should be able to: 

  • Identify disease course milestones and diagnostic criteria of Rett syndrome

  • Formulate effective strategies to integrate members of the interdisciplinary care team in the treatment of patients with Rett syndrome

  • Analyze the efficacy and safety data for new and emerging treatments for Rett syndrome

  • Devise strategies for improving the caregiver burden in Rett syndrome

  • Construct a comprehensive treatment plan for a patient with Rett syndrome


Clinical Care Options, LLC (CCO) requires instructors, planners, managers, and other individuals who are in a position to control the content of this activity to disclose all financial conflicts of interest (COI) they may have with ineligible companies. All relevant COI are thoroughly vetted and mitigated according to CCO policy. CCO is committed to providing its learners with high-quality CME/CE activities and related materials that promote improvements or quality in healthcare and not a specific proprietary business interest of an ineligible company.

The faculty reported the following relevant financial relationships or relationships to products or devices they have with ineligible companies related to the content of this educational activity:

Primary Author

Arthur A. Beisang, MD

Complex Care Pediatrician
Gillette Children’s Specialty Healthcare
Assistant Professor of Pediatrics
University of Minnesota
Minneapolis, Minnesota

Arthur A. Beisang, MD: consultant/advisor/speaker: Acadia.

The planners and content peer reviewers from Clinical Care Options, LLC and the International Rett Syndrome Foundation do not have any relevant financial relationships to disclose.

Instructions for Credit

Participation in this self-study activity should be completed in approximately 0.25 hours. To successfully complete this activity and receive credit, participants must follow these steps during the period from May 22, 2024, through May 21, 2025:

  1. Login or Sign Up for an account by clicking at the top of this page.
  2. Read the target audience, learning objectives, and faculty disclosures.
  3. View and study the content in its entirety.
  4. Submit answers to the posttest questions and evaluation questions online.

You must receive a test score of at least 65 and respond to all evaluation questions to receive a certificate. After submitting the evaluation, you may access your online certificate by selecting the certificate link on the confirmation page. Records of all CME/CE activities completed can be found on the "My Certificates" page. There are no costs/fees for this activity.


This program has been made available online.

Disclosure of Unlabeled Use

This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. The planners of this activity do not recommend the use of any agent outside of the labeled indications.

The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of the planners. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.


Participants have an implied responsibility to use the newly acquired information to enhance patient outcomes and their own professional development. The information presented in this activity is not meant to serve as a guideline for patient management. Any procedures, medications, or other courses of diagnosis or treatment discussed or suggested in this activity should not be used by clinicians without evaluation of their patient’s conditions and possible contraindications and/or dangers in use, review of any applicable manufacturer’s product information, and comparison with recommendations of other authorities.


Joint Accreditation Statement

In support of improving patient care, this activity has been planned and implemented by Clinical Care Options, LLC (CCO) and the International Rett Syndrome Foundation. Clinical Care Options, LLC (CCO)  is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

Physician Continuing Medical Education

CCO designates this enduring material for a maximum of 0.25 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Nursing Continuing Professional Development

The maximum number of hours awarded for this Nursing Continuing Professional Development activity is 0.25 contact hours.

Continuing Pharmacy Education

CCO designates this continuing education activity for 0.25 contact hours (0.025 CEUs) of the Accreditation Council for Pharmacy Education. Universal Activity Number - JA4008176-0000-24-163-H01-P 

Type of Activity: Knowledge

Upon successfully completing the post-test with a score of 65 or better and the activity evaluation form, transcript information will be sent to the NABP CPE Monitor Service within 60 days.

CME Passport

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The CME credits that physicians earn from this activity will be submitted to ACCME's CME Passport, a free, centralized web application where you can create a personalized account to view, track, and generate transcripts of your reported CME credit. Visit to create your account.