eCase - Surgeon Perspective: Module

CE / CME

Immune Checkpoint Inhibitor–Based Therapy for Early-Stage Lung Cancer: Surgeon Perspective

Pharmacists: 0.75 contact hour (0.075 CEUs)

Physicians: Maximum of 0.75 AMA PRA Category 1 Credit™

Nurses: 0.75 Nursing contact hour

Released: December 01, 2021

Expiration: November 30, 2022

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Neoadjuvant Immune Checkpoint Inhibitor Therapy in Early-Stage Lung Cancer References

References

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Wu Y, Tsuboi M, He J, et al. Osimertinib in resected EGFR-mutated non-small-cell lung cancer. N Engl J Med. 2020;383:1711-1723.
Felip E, Altorki N, Zhou C, et al. Adjuvant atezolizumab after adjuvant chemotherapy in resected stage IB-IIIA non-small-cell lung cancer (Impower010): a randomised, multicentre, open-label, phase 3 trial. Lancet. 2021;398:1344-1357.
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Goldstraw P, Chansky K, Crowley J, et al. The IASLC lung cancer staging project: proposals for revision of the TNM stage groupings in the forthcoming (eighth) edition of the TNM classification for lung cancer. J Thorac Oncol. 2016;11:39-51.
Forde PM, Chaft JE, Smith KN, et al. Neoadjuvant PD-1 blockade in resectable lung cancer. N Engl J Med. 2018;378:1976.
Huynh C, Walsh LA, Spicer JD. Surgery after neoadjuvant immunotherapy in patients with resectable non-small cell lung cancer. Transl Lung Cancer Res. 2021;10:563-580.
Hellmann MD, Chaft JE, William WB Jr, et al. Pathological response after neoadjuvant chemotherapy in resectable non-small-cell lung cancers: proposal for the use of major pathological response as a surrogate endpoint. Lancet Oncol. 2014;15:e42-50.
Ferreira V, Minnella EM, Awasthi R, et al. Multimodal prehabilitation for lung cancer surgery: a randomized controlled trial. Ann Thorac Surg. 2021;112:1600-1608.
Schmid S, Minnella EM, Najmeh S, et al. Neoadjuvant prehabilitation therapy for locally advanced non-small-cell lung cancer: optimizing outcomes through the trajectory of care. Presented at: 57th Annual Meeting of the American Society of Clinical Oncology Meeting; June 4-8, 2021. Abstract e20545.
Brandt WS, Yan W, Zhou J, et al. Outcomes after neoadjuvant or adjuvant chemotherapy for cT2-4N0-1 non-small cell lung cancer: a propensity-matched analysis. J Thorac Cardiovasc Surg. 2019;157:743-753.
ClinicalTrials.gov. A study of atezolizumab as neoadjuvant and adjuvant therapy in resectable non-small cell lung cancer (NSCLC) – Lung cancer mutation consortium (LCMC3). clinicaltrials.gov/ct2/show/NCT02927301. Accessed November 16, 2021.
Lee JM, Chaft J, Nicholas A, et al: Surgical and clinical outcomes with neoadjuvant atezolizumab in resectable stage IB–IIIB NSCLC: LCMC3 trial primary analysis. Presented at: 22nd World Conference On Lung Cancer of the International Association for the Study of Lung Cancer; January 28-31, 2021. Abstract PS02.05.
Shu CA, Gainor JF, Awad MM, et al. Neoadjuvant atezolizumab and chemotherapy in patients with resectable non-small-cell lung cancer: an open-label, multicentre, single-arm, phase 2 trial. Lancet Oncol. 2020;21:786-795.
Provencio M, Nadal E, Insa A, et al. Neoadjuvant chemotherapy and nivolumab in resectable non-small-cell lung cancer (NADIM): an open-label, multicentre, single-arm, phase 2 trial. Lancet Oncol. 2020;21:1413-1422.
Forde PM, Spicer J, Lu S, et al. Nivolumab (NIVO) + platinum-doublet chemotherapy (chemo) vs chemo as neoadjuvant treatment (tx) for resectable (IB-IIIA) non-small cell lung cancer (NSCLC) in the phase 3 checkmate 816 trial. Presented at: American Association for Cancer Research Annual Meeting 2021; April 10-15, 2021. Abstract CT003.
Spicer J, Wang C, Tanaka F, et al. Surgical outcomes from the phase 3 checkMate 816 trial: nivolumab (NIVO) + platinum-doublet chemotherapy (chemo) vs chemo alone as neoadjuvant treatment for patients with resectable non-small cell lung cancer (NSCLC). Presented at: 57th Annual Meeting of the American Society of Clinical Oncology Meeting; June 4-8, 2021. Abstract 8503.
ClinicalTrials.gov. A neoadjuvant study of nivolumab plus ipilimumab or nivolumab plus chemotherapy versus chemotherapy alone in early stage non-small cell lung cancer (NSCLC) (checkmate 816). clinicaltrials.gov/ct2/show/NCT02998528. Accessed November 16, 2021.
Lim EK, Batchelor TJ, Dunning J, et al. Video-assisted thoracoscopic versus open lobectomy in patients with early-stage lung cancer: one-year results from a randomized controlled trial (VIOLET). Presented at: 57th Annual Meeting of the American Society of Clinical Oncology Meeting. June 4-8, 2021. Abstract 8504.
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Osimertinib prescribing Information. Wilmington, DE: AstraZeneca Pharmaceuticals; 2021.
Atezolizumab prescribing information. South San Francisco, CA: Genentech; 2021.
Alectinib prescribing information. South San Francisco, CA: Genentech; 2021.
ClinicalTrials.gov. Pembrolizumab as neoadjuvant therapy for resectable stage IA3 to IIA non-small cell lung cancer (NSCLC). clinicaltrials.gov/ct2/show/NCT04638582. Accessed November 16, 2021.

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