Individualizing 2L+ CLL Therapy

CME

Individualizing CLL Therapy: Second-Line Treatment and Beyond

Physicians: Maximum of 0.75 AMA PRA Category 1 Credit

Released: September 16, 2024

Expiration: August 15, 2025

Activity

Progress
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Course Completed

References

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  9. Pirtobrutinib [prescribing information]. Indianapolis, IN: Eli Lilly; 2023.
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  11. Lisocabtagene maraleucel [prescribing information]. Devens, MA: Bristol-Myers Squibb Company; 2024.
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  22. Mato AR, Pagel JM, Coombs CC, et al. LOXO-305, a next generation, highly selective, non-covalent BTK inhibitor in previously treated CLL/SLL: results from the phase 1/2 BRUIN study. Presented at: 2020 American Society of Hematology Annual Meeting & Exposition; December 4-8, 2020. Abstract 542.
  23. Wang E, Mi X, Thompson MC, et al. Mechanisms of resistance to noncovalent Bruton's tyrosine kinase inhibitors. N Engl J Med. 2022;386:735-743.
  24. Montoya S, Bourcier J, Noviski M, et al. Kinase-impaired BTK mutations are susceptible to clinical-stage BTK and IKZF1/3 degrader NX-2127. Science. 2024;383:eadi5798.
  25. Liu J, Li S, Wang Q, et al. Sonrotoclax overcomes BCL2 G101V mutation-induced venetoclax resistance in preclinical models of hematologic malignancy. Blood. 2024;143:1825-1836.
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  29. Kater AP, Ye JC, Sandoval-Sus J, et al. Subcutaneous epcoritamab in patients with Richter's syndrome: early results from phase 1b/2 trial (EPCORE CLL-1) Blood. 2022;140(supplement 1):850.