PARPi Combos in Prostate Cancer
Novel PARP Inhibitor–Based Combinations Targeting Improved Patient Outcomes in Prostate Cancer

Released: April 12, 2021

Expiration: April 11, 2022

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References

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  4. Olaparib [prescribing information]. Cambridge, UK: AstraZeneca; 2020.
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  25. ClinicalTrials.gov. Talazoparib + enzalutamide vs. enzalutamide monotherapy in mCRPC (TALAPRO-2). clinicaltrials.gov/ct2/show/NCT03395197. Accessed March 30, 2021.
  26. ClinicalTrials.gov. A clinical study evaluating the benefit of adding rucaparib to enzalutamide for men with metastatic prostate cancer that has become resistant to testosterone-deprivation therapy (CASPAR). clinicaltrials.gov/ct2/show/NCT04455750. Accessed March 30, 2021.
  27. Rao A, Morris D, Assikis VJ, et al. Rucaparib plus enzalutamide in patients (pts) with metastatic castration-resistant prostate cancer (mCRPC): Pharmacokinetics (PK) and safety data from the phase Ib RAMP study. Presented at: 2021 American Society of Clinical Oncology Genitourinary Cancers Symposium; February 11-13, 2021. Abstract 79.
  28. ClinicalTrials.gov. Study of oral rucaparib with other anticancer agents in metastatic castration resistant prostate cancer patients (RAMP). clinicaltrials.gov/ct2/show/NCT04179396. Accessed March 30, 2021.
  29. Chi KN, Rathkopf DE, Attard G, et al. A phase III randomized, placebo-controlled, double-blind study of niraparib plus abiraterone acetate and prednisone versus abiraterone acetate and prednisone in patients with metastatic prostate cancer (MAGNITUDE). Presented at: 2020 American Society of Clinical Oncology Annual Meeting; May 29-31, 2020. Abstract TPS5588.
  30. ClinicalTrials.gov. A study of niraparib in combination with abiraterone acetate and prednisone versus abiraterone acetate and prednisone for treatment of participants with metastatic prostate cancer (MAGNITUDE). clinicaltrials.gov/ct2/show/NCT03748641. Accessed March 30, 2021.
  31. Vikas P, Borcherding N, Chennamadhavuni A, et al. Therapeutic potential of combining PARP inhibitor and immunotherapy in solid tumors. Front Oncol. 2020;10:570.
  32. Yu EY, Rodriguez JMMP, Gravis G, et al. Pembrolizumab (pembro) plus olaparib in patients (pts) with docetaxel-pretreated metastatic castration-resistant prostate cancer (mCRPC): KEYNOTE-365 cohort A efficacy, safety, and biomarker results. Presented at: 2020 American Society of Clinical Oncology Annual Meeting; May 29-31, 2020. Abstract 5544.
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  40. ClinicalTrials.gov. Phase I/II study of the anti-programmed death ligand-1 antibody MEDI4736 in combination with olaparib and/or cediranib for advanced solid tumors and advanced or recurrent ovarian, triple negative breast, lung, prostate and colorectal cancers. clinicaltrials.gov/ct2/show/NCT02484404. Accessed March 30, 2021.
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  49. ClinicalTrials.gov. Olaparib with or without cediranib in treating patients with metastatic castration-resistant prostate cancer. clinicaltrials.gov/ct2/show/NCT02893917. Accessed March 30, 2021.
  50. ClinicalTrials.gov. Niraparib with standard combination radiation therapy and androgen deprivation therapy in treating patients with high risk prostate cancer (NADIR). clinicaltrials.gov/ct2/show/NCT04037254. Accessed March 30, 2021.