ART Management When HTE

CE / CME

Foundations of ART Management in Heavily Treatment–Experienced Patients

Pharmacists: 1.00 contact hour (0.1 CEUs)

Physicians: Maximum of 1.00 AMA PRA Category 1 Credit

Released: October 06, 2022

Expiration: October 05, 2023

Eric S. Daar
Eric S. Daar, MD

Activity

Progress
1
Course Completed

References

  1. Panel on Antiretroviral Guidelines for Adults and Adolescents. Guidelines for the use of antiretroviral agents in adults and adolescents with HIVDepartment of Health and Human Services. hiv.gov/en/guidelines/adult-and-adolescent-arv. Accessed September 28, 2022.
  2. gov. A timeline of the history of HIV and AIDS. hiv.gov/hiv-basics/overview/history/hiv-and-aids-timeline. Accessed September 28, 2022.
  3. Bajema KL, Nance RM, Delaney JAC, et al. Substantial decline in heavily treated therapy-experienced persons with HIV with limited antiretroviral treatment options. AIDS. 2020;34:2051-2059.
  4. Henegar CD, Underwood M, Ragone L, et al. Trends and characteristics of HIV-1 drug resistance in the United States (2012-2018). Presented at: 2020 Conference on Retroviruses and Opportunistic Infections; March 8-11, 2020. Abstract 521.
  5. Castagna A, Maggiolo F, Penco G, et al. Dolutegravir in antiretroviral-experienced patients with raltegravir- and/or elvitegravir-resistant HIV-1: 24-week results of the phase III VIKING-3 study. J Infect Dis. 2014;210:354-362.
  6. Darunavir prescribing information. Titusville, NJ: Janssen Therapeutics; 2022.
  7. Paton NI, Kityo C, Thompson J, et al. Nucleoside reverse-transcriptase inhibitor cross-resistance and outcomes from second-line antiretroviral therapy in the public health approach: an observational analysis within the randomised, open-label, EARNEST trial. Lancet HIV. 2017;4:e341-e348.
  8. Aboud M, Orkin C, Podzamczer D, et al. Efficacy and safety of dolutegravir-rilpivirine for maintenance of virological suppression in adults with HIV-1: 100-week data from the randomised, open-label, phase 3 SWORD-1 and SWORD-2 studies. Lancet HIV. 2019;6:e576-e587.
  9. Brown D, Kaplan R, Losso M, et al. Efficacy of second-line dolutegravir plus 2 nucleoside reverse transcriptase inhibitors by baseline nucleoside reverse transcriptase inhibitor resistance and nucleoside reverse transcriptase inhibitor use in the DAWNING study. Antivir Therapy. 2022:1-6.
  10. Paton NI, Musaazi J, Kityo C, et al. Dolutegravir or darunavir in combination with zidovudine or tenofovir to treat HIV. N Engl J Med. 2021;385:330-341.
  11. Paton NI, Musaazi J, Kityo C, et al. Efficacy and safety of dolutegravir or darunavir in combination with lamivudine plus either zidovudine or tenofovir for second-line treatment of HIV infection (NADIA): week 96 results from a prospective, multicentre, open-label, factorial, randomised, non-inferiority trial. Lancet HIV. 2022;9:e381-e393.
  12. Ibalizumab prescribing information. Montreal, Quebec: Theratechnologies.; 2021.
  13. Fostemsavir prescribing information. Research Triangle Park, NC: ViiV; 2022.
  14. gov. Study to evaluate the safety and efficacy of lenacapavir (GS-6207) in combination with an optimized background regimen (OBR) in heavily treatment experienced participants living with HIV-1 infection with multidrug resistance (CAPELLA). clinicaltrials.gov/ct2/show/NCT04150068. Accessed September 28, 2022.
  15. Emu B, Fessel J, Schrader S, et al. Phase 3 study of ibalizumab for multidrug-resistant HIV-1. N Engl J Med. 2018;379:645-654.
  16. Emu B, Fessel J, Schrader S, et al. 48-week safety and efficacy on-treatment analysis of ibalizumab in patients with multi-drug resistant HIV-1. Presented at: 2017 IDWeek; October 4-8, 2017. Abstract 1686.
  17. Emu B, Weinheimer S, Cohen Z, et al. Analysis of patients completing the ibalizumab phase III trial and expanded access program. Presented at: HIV Glasgow 2018; October 28-31, 2018. Abstract O345.
  18. DeJesusE, Emu B, Weinheimer S, et al. Outcomes of patients not achieving primary endpoint from an ibalizumab phase III trial. Presented at: HIV Glasgow 2018; October 28-31, 2018. Abstract P064.
  19. Emu B, Lalezari J, Kumar P, et al. Ibalizumab: 96-week data and efficacy in patients resistant to common antiretrovirals. Presented at: 2019 Conference on Retroviruses and Opportunistic Infections; March 4-7, 2019. Abstract 485.
  20. Kozal M, Aberg J, Pialoux G, et al. Fostemsavir in adults with multidrug-resistant HIV-1 infection. N Engl J Med. 2020;382:1232-1243.
  21. Pialoux G, Kozal M, Aberg J, et al. Phase 3 study of fostemsavir in heavily treatment-experienced HIV-1-infected participants: BRIGHTE week 24 subgroup analysis in randomized cohort subjects. Presented at: 2018 International AIDS Conference; July 23-27, 2018. Abstract THPEB045.
  22. Lataillade M, Lalezari J, Aberg J, et al. Week 96 safety and efficacy of the novel HIV-1 attachment inhibitor prodrug fostemsavir in heavily treatment-experienced participants infected with multi-drug resistant HIV-1 (BRIGHTE study). Presented at: 2019 International AIDS Society Conference on HIV Science; July 21-24, 2019. Abstract
  23. Ogbuagu O, Segal-Maurer S, Brinson C, et al. Long-acting lenacapavir in people with multidrug resistant HIV-1: Week 52 results. Presented at: 2022 Conference on Retroviruses and Opportunistic Infections; February 12-16, 2022. Abstract 491.
  24. Segal-Maurer S, DeJesus E, Stellbrink HJ, et al. Capsid inhibition with lenacapavir in multidrug-resistant HIV-1 infection. N Engl J Med. 2022;386:1793-1803. 
  25. Kumar P, Gupta S, Segal-Maurer S, et al. Injection site reaction experience in clinical studies of people using lenacapavir for HIV treatment. Presented at: 2022 International AIDS Conference; July 29-August 2, 2022. Abstract EPB184.
  26. Eron JJ, Young B, Cooper DA, et al. Switch to a raltegravir-based regimen versus continuation of a lopinavir-ritonavir-based regimen in stable HIV-infected patients with suppressed viraemia (SWITCHMRK 1 and 2): two multicentre, double-blind, randomised controlled trials. Lancet. 2010;375:396-407.
  27. Hagins D, Kumar P, Saag M, et al. Switching to bictegravir/emtricitabine/tenofovir alafenamide in black americans with HIV-1: a randomized phase 3b, multicenter, open-label study. J Acquir Immune Defic Syndr. 2021;88:86-95. 
  28. Sax PE, Andreatta K, Molina JM, et al. High efficacy of switching to bictegravir/emtricitabine/tenofovir alafenamide in people with suppressed HIV and preexisting M184V/I. AIDS. 2022;36:1511-1520. 
  29. Sax PE, Rockstroh JK, Luetkemeyer AF, et al. Switching to bictegravir, emtricitabine, and tenofovir alafenamide in virologically suppressed adults With Human Immunodeficiency Virus. Clin Infect Dis. 2021;73:e485-e493.
  30. Sax PE, Rockstroh JK, Luetkemeyer AF, et al. Switching to a single-tablet regimen bictegravir, emtricitabine, and tenofovir alafenamide (B/F/TAF) from dolutegravir (DTG) plus emtricitabine and either tenofovir alafenamide or tenofovir disoproxil fumarate (F/TAF or F/TDF). Presented at: 2019 International AIDS Society Conference on HIV Science; July 21-24, 2019. Abstract MOAB0105.