Expert Analysis

CME

Key Studies in Myelodysplastic Syndromes and Myeloproliferative Neoplasms: CCO Independent Conference Highlights of the 2020 Virtual ASH Annual Meeting

Physicians: Maximum of 1.00 AMA PRA Category 1 Credit

Released: February 16, 2021

Expiration: February 15, 2022

Amy E. DeZern
Amy E. DeZern, MD, MHS
Srdan Verstovsek
Srdan Verstovsek, MD, PhD

Activity

Progress
1
Course Completed

References

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  4. Mascarenhas J, Komrokji R, Cavo M, et al. Favorable overall survival with imetelstat treatment correlates with other clinical benefits in intermediate 2 or high-risk myelofibrosis relapsed/refractory to Janus kinase inhibitor. Program and abstracts of the 2020 American Society of Hematology Annual Meeting; December 5-8, 2020. Abstract 53.
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  8. Verstovsek S, Mascarenhas H, Kremyanskaya M, et al. CPI-0610, bromodomain and extraterminal domain protein (BET) inhibitor, as “add-on” to ruxolitinib, in advanced myelofibrosis patients with suboptimal response: update of MANIFEST phase 2 study. Program and abstracts of the 2020 European Hematology Association Annual Meeting; June 11-21, 2020. Abstract 56.
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  12. Verstovsek S, Mesa RA, Gotlib J, et al. A double-blind placebo-controlled trial of ruxolitinib for myelofibrosis. N Engl J Med. 2012;366:799-807.
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  23. Gisslinger H, Klade C, Georgiev P, et al. Long-term use of ropeginterferon alpha-2b in polycythemia vera: 5-year results from a randomized controlled study and its extension. Program and abstracts of the 2020 American Society of Hematology Annual Meeting; December 5-8, 2020. Abstract 481.
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  43. Bennett JM, Cazzola M, deCastro C, et al. Consensus statement on iron overload in myelodysplastic syndromes. Am J Hematol. 2008;83:858-861.
  44. Provenzano R, Besarab A, Wright S, et al. Roxadustat (FG-4592) versus epoetin alfa for anemia in patients receiving maintenance hemodialysis: a phase 2, randomized, 6- to 19-week, open-label, active-comparator, dose-ranging, safety and exploratory efficacy study. Am J Kid Dis. 2016;67:912-924.
  45. Henry DH, Glaspy J, Harrup RA, et al. Oral roxadustat demonstrates efficacy in anemia secondary to lower-risk myelodysplastic syndrome irrespective of ring sideroblasts and baseline erythropoietin levels. Program and abstracts of the 2020 American Society of Hematology Annual Meeting; December 5-8, 2020. Abstract 1277.
  46. ClinicalTrials.gov. Efficacy and safety of FG-4592 for treatment of anemia in patients with lower risk MDS with low red blood cell transfusion burden. Available at: https://clinicaltrials.gov/ct2/show/NCT03263091. Accessed February 10, 2021.