eCase - ASH 2022 Leukemia Highlights

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Key Studies in Leukemias: Independent Conference Coverage of ASH 2022

Amir T. Fathi, MD

Eunice S. Wang, MD

Activity

Introduction

If you are a practicing healthcare professional, how many patients with leukemia do you provide care for in a typical month?

You are discussing the results of the phase I/II study of azacitidine/venetoclax/magrolimab triplet therapy in patients with newly diagnosed or relapsed/refractory (R/R) AML with your oncology fellow in clinic. Which of the following would you tell her based on the results reported at ASH 2022?

Which of the following was reported regarding differentiation syndrome (DS) with ziftomenib from the phase Ib KOMET-001 study in patients with R/R AML and KMT2A or NPM1 mutations?

Based on results of the ECOG-ACRIN E1910 trial, which of the following consolidation regimens would you recommend for a young, fit adult with newly diagnosed Philadelphia chromosome (Ph)–negative B-cell ALL (B-ALL) who is measurable residual disease (MRD) negative?

Based on evidence from the ASC4MORE trial, which of the following patients with chronic-phase CML would you consider for potential enrollment on a clinical trial with asciminib?