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FLT3 in AML

CME

Deciphering FLT3 in AML: Biological Underpinnings, Expression Patterns, and Molecular Profiling

Physicians: Maximum of 0.50 AMA PRA Category 1 Credit

Released: July 10, 2025

Expiration: January 09, 2026

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How many people with acute myeloid leukemia (AML) do you provide care for in a typical month?

Which best describes your practice setting?

Which of the following most accurately describes the significance of FLT3 mutations in patients with AML?

A 45-year-old patient is newly diagnosed with AML. Her white blood cell count is 105,000 with 87% circulating blasts. A blood sample is taken for testing and she is started on intensive induction chemotherapy. Polymerase chain reaction (PCR) testing of peripheral blood reported on Day 7 reveals a NPM1 mutation and FLT3-ITD mutation with an FLT3-ITD allelic ratio of 0.1. Based on current evidence and guidelines, what is the most appropriate next step regarding targeted therapy?